Without being the biggest expert in this area, I have always had luck striking from cuttings, or generally plants that have sustained damage to the top have started offshooting around the damaged area.
What plants do you have?
I have an oreocereus doelzianus which I puchased in a clump, with one stem damaged at the tip, which has started to pup around the damaged area now. I have another oreocereus cutting (a roundish clumping one, not 100% sure which it is exactly) which i got at the C&S Society show in November, which took pretty easily. Some rebutias and mamms I have with tip damage have pupped like crazy around the damaged area. The opuntias always behave in the same fashion.
The only really tricky plants I have had are a type of euphorbia which just keeps dying off every time I try to strike from cuttings and the base is always rotting...otherwise I think as a general rule with the hardier plants you can do it